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Reslslianee
oll
Gancer
Gell
When cancer
patients with similar
diagnosis are
administered
the same chemotherapeutic agents, the response may
not be
all
promising.
lnitially
some patients
may show
a
positive
result.
Subsequent treatments may indicate
poor
response.
Cancer cells
can
develop
drug
resistance.
The multi-drug
resistance
gene
(MDR-|)
is
the
main
reason
for
this
phenomenon. This
gene
promotes the production
of
the
'P-glucoprotein'
in
the cell.
The
'P-glucoprotein'
is
instrumental
in
pumping out
the N-cells
which
normally carry
the anti-cancer medication
to
invade
and
destroy
the
caincer
cells.
This
'pumping-out'
action
prevents
the
medication from
reaching an effective
concentration
levelto
effect
killing
on
the
cancer
cells.
Under
labortory
tests
and
clinical
observations,
this multi-drug
resistance
phenomenon
may
be
overcome. But the solution
is not
easy. Cancer cells
are
far
more
elusive and
difficult
to treat than bacteria.
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